OUR PUBLICATIONS

Find an ongoing list of our publications here.

For any questions regarding our research please contact Professor Schroeder: avids@technion.ac.il

52. Collagenase Nanoparticles Enhance the Penetration of Drugs Into Pancreatic Tumor

Assaf Zinger, Lilach Koren, Omer Adir, Maria Poley, Mohammed Alyan, Zvi Yaari, Nadav Noor, Nitzan Krinsky, Assaf Simon, Hadas Gibori, Majd Krayem, Yelena Mumblat, Shira Kasten, Sivan Ofir, Eran Fridman, Neta Milman, Michael M. Lübtow, Lior Liba, Jeny Shklover, Janna Shainsky-Roitman, Yoav Binenbaum, Dov Hershkovitz, Ziv Gil, Tal Dvir, Robert Luxenhofer, Ronit Satchi-Fainaro, Avi Schroeder

ACS Nano, 2019 (download)

 

51. Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine

Omer Adir, Maria Poley, Gal Chen, Sahar Froim, Nitzan Krinsky, Jeny Shklover, Janna Shainsky-Roitman, Twan Lammers and Avi Schroeder

Advanced  Materials, 2019 (download)

50. Tailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells

Hanan Abumanhal-Masarweh, Dana da Silva, Maria Poley, Assaf Zinger, Evgenya Goldman, Nitzan Krinsky, Ron Kleiner, Gal Shenbach, Josh E.Schroeder, Jeny Shklover, Janna Shainsky-Roitman, Avi Schroeder

Journal of Controlled Release, 2019 (download)

49. Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin

Hanan Abumanhal Masarweh, Lilach Koren, Assaf Zinger, Zvi Yaari, Nitzan Krinsky, Galoz Kaneti, Nitsan Dahan, Yael Lupu-Haber, Edith Suss-Toby, Esther Weiss-Messer, Michal Schlesinger-Laufer, Janna Shainsky-Roitman, Avi Schroeder

Journal of Controlled Release, 2019, 296, 1-13 (download)

48. Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma

Yoav Binenbaum, Eran Fridman, Zvi Yaari, Neta Milman, Avi Schroeder, Gil Ben David, Tomer Shlomi and Ziv Gil

Cancer Research, 2018 (download)

47. Therapeutic nanoparticles penetrate leaves and deliver nutrients to agricultural crops.

Avishai Karny, Assaf Zinger, Ashima Kajal, Janna Shainsky-Roitman & Avi Schroeder

Scientific reports, 2018, 8(1), 7589 (download)

46. Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems

Dana da Silva, Maya Kaduri, Maria Poley, Omer Adir, Nitzan Krinsky, Janna Shainsky-Roitman, Avi Schroeder

Chemical Engineering Journal, 2018 (download)

45. Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery

Yarden Shtenberg, Mor Goldfeder, Hodaya Prinz, Janna Shainsky, Yasmine Ghantous, Imad Abu ElNaaj, Avi Schroeder, Havazelet Bianco-Peled

International journal of biological macromolecules, 2018, 111, 62-69 (download)

44. Proteolytic Nanoparticles Replace a Surgical Blade by Controllably Remodeling the Oral Connective Tissue

Assaf Zinger, Omer Adir, Matan Alper, Assaf Simon, Maria Poley, Chen Tzror, Zvi Yaari, Majd Krayem, Shira Kasten, Guy Nawy, Avishai Herman, Yael Nir, Sharon Akrish, Tidhar Klein, Janna Shainsky-Roitman, Dov Hershkovitz, Avi Schroeder

ACS Nano, 2018, 12,2, 1482-1490 (download)

43. Synthetic Cells Synthesize Therapeutic Proteins inside Tumors

Nitzan Krinsky, Maya Kaduri, Assaf Zinger, Janna Shainsky-Roitman, Mor Goldfeder, Itai Benhar, Dov Hershkovitz, and Avi Schroeder

Advanced healthcare materials, 2017 (download)

42. Elephant p53 (EP53) enhances and restores p53-mediated apoptosis in human and canine osteosarcoma

Lisa M. Abegglen, Cristhian Toruno, Lauren N. Donovan, Rosann Robinson, Mor Goldfeder, Genevieve Couldwell, Wendy K. Kiso, Dennis L. Schmitt, Aleah F. Caulin, Carlo C. Maley, Avi Schroeder and Joshua D. Schiffman

Clinical Cancer Research, 2017

41. Alginate modified with maleimide-terminated PEG as drug carriers with enhanced mucoadhesion

Yarden Shtenberg, Mor Goldfeder, Avi Schroeder, Havazelet Bianco-Peled 

Carbohydrate polymers, 2017, 175, 337 (download)

40. Nanoparticles target early-stage breast cancer metastasis in vivo

Evgeniya Goldman, Assaf Zinger, Dana da Silva, Zvi Yaari, Ashima Kajal, Dikla Vardi-Oknin, Mor Goldfeder, Josh E Schroeder, Janna Shainsky-Roitman, Dov Hershkovitz, Avi Schroeder

Nanotechnology, 2017, 28 (43), 43LT01 (download)

39. Autonomous bacterial nanoswimmers target cancer.

Nour Zoaby, Janna Shainsky-Roitman, Samah Badarneh, Hanan Abumanhal, Alex Leshansky, Sima Yaron, Avi Schroeder

Journal of Controlled Release, 2017, 257, 68-75 (download)

38. Elephant p53 (EP53) expression induces apoptosis of human cancer cells

Lisa M Abegglen, Lauren N Donovan, Genevieve Couldwell, Rosann Robinson, Cristhian Toruno, Mor Goldfeder, Wendy K Kiso, Dennis L Schmitt, Aleah F Caulin, Katrin P Guillen, Bryan E Welm, Carlo C Maley, Avi Schroeder, Joshua D Schiffman

Cancer Research, 2017, 77 (13 Supplement), 2153-2153 

37. Anti-viral RNAi nanoparticles protect shrimp against white spot diseaseShai Ufaz, Adi Baltar, Chen Tsror, Shai Einbender, Ori Koshet, Zvi Yaari, Janna Shainsky-Roitman, Avi Schroeder

Molecular Systems Design & Engineering, 2017 (download)

36. Theranostic barcoded nanoparticles for personalized cancer medicine

Zvi Yaari, Dana Da Silva, Assaf Zinger, Evgeniya Goldman, Ashima Kajal, Rafi Tshuva, Efrat Barak, Nitsan Dahan, Dov Hershkovitz, Mor Goldfeder, Janna Shainsky Roitman, Avi Schroeder 

Nature Communications, 2016, 7, 13325 (download)

35. A Simple and Rapid Method for Preparing a Cell-Free Bacterial Lysate for Protein Synthesis.

Nitzan Krinsky, Maya Kaduri, Janna Shainsky-Roitman, Mor Goldfeder, Eran Ivanir, Itai Benhar, Yuval Shoham, Avi Schroeder

Nature cell biology, 18(9), 1006 (download)

34. Elephant TP53 (ep53) retrogene protein expression enhances cellular apoptosis in response to DNA damage.

Lisa M. Abegglen, Rosann Robinson, Lauren Donovan, Aleah F. Caulin, Mor Goldfeder, Avi Schroeder, Carlo C. Maley and Joshua D. Schiffman

Cancer Research, 2016​

33. Low-frequency ultrasound for the delivery of therapeutics to the gastrointestinal tract.

Carl M. Schoellhammer, Avi Schroeder, and Ruby Maa

The Journal of the Acoustical Society of America, 2016, 139, 2091

32. Autonomous bacterial nanoswimmers target cancer 

Nour Zoaby, Janna Shainsky-Roitman, Samah Badarneh, Hanan Abumanhal, Alex Leshansky, Sima Yaron, Avi Schroeder.

Journal of Controlled Release, 2016 (download)

31. Melanoma miRNA trafficking controls tumour primary niche formation. 

Shani Dror, Laureen Sander, Hila Schwartz, Danna Sheinboim, Aviv Barzilai, Yuval Dishon, Sebastien Apcher, Tamar Golan, Shoshana Greenberger, Iris Barshack, Hagar Malcov, Alona Zilberberg, Lotan Levin, Michelle Nessling, Yael Friedmann, Vivien Igras, Ohad Barzilay, Hananya Vaknine, Ronen Brenner, Assaf Zinger, Avi Schroeder, Pinchas Gonen, Mehdi Khaled, Neta Erez, Jörg D. Hoheisel and Carmit Levy

Nature Cell Biology, 2016, 18, 1006–1017 (download)

30. Ultrasound- mediated gastrointestinal drug delivery.

Carl M. Schoellhammer, Avi Schroeder, Ruby Maa, Gregory Yves Lauwers, Albert Swiston, Michael Zervas, Ross Barman, Angela M. DiCiccio, William R. Brugge, Daniel G. Anderson, Daniel Blankschtein, Robert Langer and Giovanni Traverso

Science Translational Medicine, 2015, 7 (310), ra 168 (download)

29. Microneedles for Drug Delivery via the Gastrointestinal Tract

Giovanni Traverso, Carl M. Schoellhammer, Avi Schroeder, Ruby Maa, Gregory Y. Lauwers, Baris E. Polat, Daniel G. Anderson, Daniel Blankschtein, Robert Langer

Journal of Pharmaceutical Sciences, 2015, 104 (2), 362-367 (download

28. Small RNA combination therapy for lung cancer

Wen Xue, James E. Dahlmana, Tuomas Tammela, Omar F. Khana, Sabina Sood, Apeksha Davea,b, Wenxin Cai, Leilani M. Chirino, Gillian R. Yang, Roderick Bronson, Denise G. Crowley, Gaurav Sahay, Avi Schroeder, Robert Langer, Daniel G. Anderson, and Tyler Jacks

PNAS Proceedings of the National Academy of Sciences, 2014, 111 (34), E3553-E3561 (download)

27. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.

James E. Dahlman, Carmen Barnes, Omar F. Khan, Aude Thiriot, Siddharth Jhunjunwala, Taylor E. Shaw, Yiping Xing, Hendrik B. Sager, Gaurav Sahay, Lauren Speciner, Andrew Bader, Roman L. Bogorad, Hao Yin, Tim Racie, Yizhou Dong, Shan Jiang, Danielle Seedorf, Apeksha Dave, Kamaljeet Singh Sandhu, Matthew J. Webber, Tatiana Novobrantseva, Vera M. Ruda, Abigail K. R. Lytton-Jean, Christopher G. Levins, Brian Kalish, Dayna K. Mudge, Mario Perez, Ludmila Abezgauz, Partha Dutta, Lynelle Smith, Klaus Charisse, Mark W. Kieran, Kevin Fitzgerald, Matthias Nahrendorf, Dganit Danino, Rubin M. Tuder, Ulrich H. von Andrian, Akin Akinc, Dipak Panigrahy, Avi Schroeder, Victor Koteliansky, Robert Langer & Daniel G. Anderson

Nature Nanotechnology, 2014, 9(8):648-655 (download)

26. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. 

Yizhou Dong, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yunlong Zhang, Delai Chen, Roman L. Bogorad, Hao Yin, Yi Chen, Arturo J. Vegas, Christopher A. Alabi, Gaurav Sahay, Karsten T. Olejnik, Weiheng Wang, Avi Schroeder, Abigail K. R. Lytton-Jean, Daniel J. Siegwart, Akin Akinc, Carmen Barnes, Scott A. Barros, Mary Carioto, Kevin Fitzgerald, Julia Hettinger, Varun Kumar, Tatiana I. Novobrantseva, June Qin, William Querbes, Victor Koteliansky, Robert Langer, and Daniel G. Anderson

PNAS Proceedings of the National Academy of Sciences, 2013, 201322937 (download)

25. Using ultrasound to formulate nanotherapeutics. 

Avi Schroeder, Chimica Oggi –

Chemistry Today – vol. 31(6) November/December 2013 (download)

24. The evolution of tumor-targeted drug delivery: From the EPR effect to nanoswimmers. 
Avi Schroeder, Nour Zoabi, Adi Golani-Armon, Assaf Zinger, Maayan Reshef, Zvi Yaari, Dikla Vardi-Oknin, Zohar Shatsberg, Aseel Shomar, Janna Shainsky-Roitman. 

Israel Journal of Chemistry. Special Issue: New Biomaterials for Therapy: Wolf Prize for Robert S. Langer; 2013 (53), 9-10, 719-727. (download)

23. Targeting nanotherapeutics to the tumor microenvironment: how accurately can we aim? 
Avi Schroeder. 

Therapeutic Delivery, 2013, 4(7), 771-773. (download)

22. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling.
Sahay Gaurav, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C,Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y,Schroeder Avi,Langer R, Anderson DG. 

Nature Biotechnology. 2013 (download)

21. Injection of vascular endothelial growth factor into knee joints induces osteoarthritis in mice.Ludin Aya, Sela J Jona, Schroeder Avi, Samuni Yuval, Nitzan DW, Amir Gail. 

Osteoarthritis Cartilage, 2012 (download)

20. Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels

Daniel A. Heller, Yair Levi, Jeisa M. Pelet, Joshua C. Doloff, Jasmine Wallas, George W. Pratt, Shan Jiang, Gaurav Sahay, Avi Schroeder, Josh E. Schroeder, Yieu Chyan, Christopher Zurenko, William Querbes, Miguel Manzano, Daniel S. Kohane, Robert Langer, Daniel G. Anderson. 

Adavanced Materials, 2012 (download)

19. Remotely-activated protein-producing nanoparticles. 

Avi Schroeder, Michael S. Goldberg Christian Kastrup Christopher G. Levins, Robert Langer and Daniel G. Anderson.

NanoLetters, 2012, 12 (6), 2685–2689. Highlighted in Nature, 2012, 484, 290. (download)

18. Alkane-modified short polyethyleneimine for siRNA delivery

Avi Schroeder, James Dahlman, Gaurav Sahay, Kevin T. Love, Yingxia Wang and Daniel G. Anderson. 

Journal of Controlled Release, 2012, 160(2), 172–176. (download)

17. Treating metastatic cancer with nanotechnology. 

Avi Schroeder, Daniel A. Heller, Monte M. Winslow, James E. Dahlman, George W. Pratt, Robert Langer, Tyler Jacks and Daniel G. Anderson,

NATURE Rev. Cancer, 2011, 12(1), 39-50. (download)

16. Nanoparticles for targeting the infarcted heart. 

Tal Dvir, Michael Bauer, Avi Schroeder, Jonathan Tsui, Daniel G. Anderson, Robert Langer, Ronglih Liao and Daniel S. Kohane,

NanoLetters, 2011, 11(10), 4411–4414. (download)

15. Liposomes for HIV prophylaxis. 

Nikita Malavia, David Zurakowski, Avi Schroeder, Anna Laury, Hila Epstein-Barash, Joseph Sodroski, Robert Langer, Navid Madani, and Daniel S. Kohane. 

Biomaterials, 2011, 32(33):8663-8. (download)

14. Boundary lubricants with exceptionally-low friction coefficients based on 2-D close-packed phosphatidylcholine liposomes. 

Ronit Golberg, Avi Schroeder, Keren Torgeman, Yechezkel Barenholz, Jacob Klein. 

Advanced Materials, 2011, 23(31):3517-21. (download)

13. Interactions between adsorbed unilamellar HSPC vesicles on mica surfaces across conditions of physiological osmolarity. 

Ronit Goldberg, Avi Schroeder, Yechezkel Barenholz, Jacob Klein. 

Biophysical Journal, 2011, 100(10) 2403-2411. (download)

12. Polyhydroxylated Fatty Alcohols Derived from Avocado Suppress Inflammatory Response and Provide Non-Sunscreen Protection Against UV-induced Damage In Skin Cells. 

Gennady Rosenblat, Shai Meretski, Joseph Segal, Mark Tarshih, Avi Schroeder, Alexandra Zanin, Malka Hochberg. 

Archives of Dermatological Research, 2011, 303(4) 239-46. (download)

11. Using Liposomes to Target Infection and Inflammation Induced by a Foreign Body Injury. 

Avi Schroeder, Keren Turjeman, Josh E. Schroeder, Meir Leibergall, Yechezkel Barenholz. 

Expert Opinion on Drug Delivery, 2010, 7(10) 1175-1189. (download)

10. Liposomes as Potential Biolubricant Additives for Wear Reduction in Human Synovial Joints. 

Gabi Verberne, Avi Schroeder, Grigory Halprin, Yechezkel Barenholz, Izhak Etsion. 

Wear, 2010, 268 (7-8) 1037-1042.. (download)

9. Liposomes Act as Effective Biolubricants for Friction Reduction in Human Synovial Joints. 

Sarit Sivan* and Avi Schroeder* (*Equal contribution), Gabi Verberne, Yulia Merkher, Dvora Diminsky, Aba Priev, Alice Maroudas, Gregory Halperin, Dorrit Nitzan, Izhak Etsion, Yechezkel Barenholz. 

Langmuir, 2010, 26 (2), 1107–1116. (download)

8. Lipid-Based Nanotherapeutics for siRNA Delivery. 

Avi Schroeder, Christopher G. Levins, Christina Cortez, Robert Langer, Daniel G. Anderson, J.

Internal Medicine, 2010, 267(1), 9-21. (download

7. A Mathematical Model of Drug Release from Liposomes by Low Frequency Ultrasound. 

Giora Enden, Avi Schroeder. 

Annals Biomedical Eng., 2009, 37 (12), 2640-2645. (download)

6. Ultrasound, Liposomes, and Drug Delivery: Principles for Using Ultrasound to Control the Release of Drugs from Liposomes. 

Avi Schroeder, Joseph Kost, Yechezkel Barenholz, 

Chem. Phys. Lipids, 2009, 162 (1-2), 1-16. (download)

5. Ultrasound Triggered Release of Cisplatin from Liposomes in Murine Tumors. 

Avi Schroeder, Reuma Honen, Keren Turjeman, Alberto Gabizon, Joseph Kost and Yechezkel Barenholz. 

J. Controlled Release, 2009, 137 (1), 63-68. (download)

4. Using PEGylated Nano-Liposomes to Target Tissue Invaded by a Foreign Body. 

Avi Schroeder, Alex Sigal, Keren Turjeman and Yechezkel Barenholz, 

J. Drug Targeting, 2008, 16 (7-8), 591-595. (download)

3. Surface Active Phospholipids as Cartilage Lubricants. 

Avi Schroeder, Gabi Verberne, Yulia Merkher, Dvora Diminsky, Alice Maroudas, Gregory Halperin, Alexandra Barbur, Dorrit Nitzan, Izhak Etsion, Yechezkel Barenholz, Sarit Sivan, 

Proc. ASME ESDA, 2008, 3, 549-553.

2. Triggered Release of Aqueous Content from Liposome-Derived Sol-Gel Nano-Capsules. 

Yael Steinberg, Avi Schroeder, Yeshayahu Talmon, Judith Schmidt, Rafail L. Khalfin, Yachin Cohen, Jean-Marie Devoisselle, Sylvie Begu, and David Avnir, 

Langmuir, 2007, 23 (24), 12024-12031. (download)

1. Controlling Liposomal Drug Release by Low-Frequency Ultrasound: Mechanism and Feasibility. 

Avi Schroeder, Yuval Avnir, Sara Weisman, Yousef Najajreh, Alberto Gabizon, Yeshayahu Talmon, Joseph Kost, and Yechezkel Barenholz, 

Langmuir, 2007, 23 (7), 4019-4025. (download)

 

Penetrating the Skin – Transdermal Drug Delivery. 

Avi Schroeder,

Galileo, 99, Nov. 2006, pp. 38 – 43.

 

Innovative Technology for Detecting Clandestine Deep Sub-Surface Tunnels. 

Avi Schroeder and Gerald Schroeder,

GDR – Global Defense Review, Apr. 2006, pp. 19-21.

 

Liposomal Drug Targeting. 

Avi Schroeder, Joseph Kost and Yechezkel Barenholz,

Galileo, 90, Feb. 2006, pp. 36-40.

 

BOOKS

 

Controlled Release of Drugs from Liposomes using Ultrasound: A view into the physical, nano-technological, and biochemical principles that govern ultrasound facilitated drug delivery. 

Avi Schroeder, Joseph Kost, Yechezkel Barenholz; VDM Verlag Dr. Müller (2010) Saarbrücken, Germany. ISBN 978-3639247282.

 

PATENTS

 

Compositions and methods for therapeutics prescreening. Zvi Yaari, Avi Schroeder. UKIPO 1414464.6.

 

Methods and kits for cell-free protein synthesis. Janna Shainsky, Yuval Shoham, Avi Schroeder. USPTO No. 62/021,748.

 

Bio-Surgical device. Assaf Zinger and Avi Schroeder. USPTO No. 61968010.

 

Microneedle pill. Carlo Giovanni Traverso, Avi Schroeder, Baris E. Polat, Carl Magnus Schoellhammer, Daniel Blankschtein, Daniel G. Anderson, Robert S. Langer. USPTO No.: 61580648.

Corneal transplant device. Houman David Hemmati, Avi Schroeder et al. USPTO No.: 61567326.

 

Ultrasound pill. Avi Schroeder, Carlo Giovanni Traverso, Baris E. Polat, Kathryn Whitehead, George K. Lewis, Daniel G. Anderson, Robert S. Langer. USPTO No. 61485957.

 

Conjugated lipomers and use thereof. Avi Schroeder, James Dahlman, Christopher G. Levins, Daniel G. Anderson, Robert S. Langer. USPTO No. 13/428,695.

 

Phosphatidylcholine lipid liposomes as boundary lubricants in aqueous media. Jacob Klein, Yechezkel Barenholz, Ronit Goldberg, Avi Schroeder. 61/355576

 

Use of glycerophspholipids for joint lubrication. Yechezkel Barehnholz, Doritt Nitzan, Izhak Etsion, Avi Schroeder, PCT WO2008/038292

 

System and Method for Transfetal (amnion-chorion) Membranes Transport. Joseph Kost, Lior Wolloch, Avi Schroeder, Israel Patla. PCT WO2007/144883.

 

Methods for affecting liposome composition by ultrasound irradiation. Avi Schroeder, Joseph Kost, Yechezkel Barenholz, PCT IL2006/001404, WO2007/066335.

 

Biopsy Needle. Avraham D. Schroeder, Joshua Schroeder, IL patent No. 181270